Present work conceptualizes a specific technology intended for chronotherapy. A major objective of chronotherapy in the treatment of several diseases is to deliver the drug in higher concentrations during the time of greatest need according to the circadian onset of diseases or symptoms..The objective of present study was to formulate and characterize single unit pulsatile drug Delivery of captopril which was aimed to release the drug after a lag time of 6 hour. Pulsatile drug delivery system (PDDS) concept was applied to that dosage form which gives lag phase followed by a burst release. The prepared pulsatile delivery system consisted of two different parts: a core tablet, containing the active ingredient, an erodible outer shell. The core tablet (CT) was prepared by 2 3 facorial design using superdisintegrants along with captopril. Coating of optimized CT was done by using hydroxyl propyl methyl cellulose (HPMC) E5, E15, and E50 at different concentration. Developed formulations were evaluated for their physical characteristics; drug content. In vitro drug release and rupture test were performed using united state pharmacopoeia paddle method at 50 rpm in 0.1 N hcl and phosphate buffer 6.8. Results revealed that both, the coating composition and coating level, are significant factors affecting drug release profile. Lag time increases as HPMC concentration increase. HPMC E50 has sufficient lag time as compare to HPMC E5 and E15 which showed compliance with chronotherapeutic objective of hypertension. Achieve chronotherapeutic release of captopril for treatment of hypertension.
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